Mitochondrial permeability transition pore in sea urchin female gametes
نویسندگان
چکیده
منابع مشابه
The mitochondrial permeability transition pore.
This chapter reviews recent advances in the identification of the structural elements of the permeability transition pore. The discovery that cyclosporin A (CsA) inhibits the pore proved instrumental. Various approaches indicate that CsA blocks the pore by binding to cyclophilin (CyP)-D. In particular, covalent labelling of CyP-D in situ by a photoactive CsA derivative has shown that pore ligan...
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Mitochondrial permeability transition pore (MPTP) is a transient structure formed in the inner mitochondrial membrane (IMM) upon oxidative challenge of the organelle. The transition is a Ca 2+ -dependent increase of permeability of IMM leading to loss of transmembrane potential (∆ψm), mitochondrial swelling and, finally, rupture of outer mitochondrial membrane leading to release of factors caus...
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Postconditioning has recently been described as a powerful cardioprotection that prevents lethal reperfusion injury. Growing evidence suggests that mitochondrial permeability transition may be a key event in postconditioning. This proposition arises from the complementary observations that: (1) conditions for the mitochondrial permeability transition pore (mPTP) opening are built up during earl...
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activities of the two enzymes recorded in Table 1 for various animals cannot be compared with each other since the supernatants of the homogenates contain only a portion of the total content of the respective hexosaminidases and since the instability of serylA-acetylgalactosaminidase3 may vary with the source. The relatively high specific activity of serylA-acetylgalactosaminidase of the oviduc...
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Objective: Extracts of Anchomanes difformis (AD) are used in folkloric medicine to treat several diseases and infections. However, their roles in mitochondrial permeability transition pore opening are not known. Material and Methods: The viability of mitochondria isolated from Wistar rat liver used in this experiment, was assessed by monitoring their swel...
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ژورنال
عنوان ژورنال: Mechanisms of Development
سال: 2018
ISSN: 0925-4773
DOI: 10.1016/j.mod.2018.07.008